USPTO Patents Application 09993647

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STATEMENT BY APPLICANT

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U.S. PATENT DOCUMENTS

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IniUals'

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NO.'

U.S. Paten) Document

Name of Pataittee or Applicant

Oslo of PutjQcalion of
Cied Document
MM.OD-YYYY

rago9, ^onwiHiB, lows, wnoio ntmvom

Passages or Relevant
Figures Appear

^ Kind Code'
Number

(If known)

Of Cftod Document

DR

AA

502.S04

U.S.

Thorns

08.01-1893

DR

AF

2.649,478

U.S.

Martin

08-15-1953

DR

AH

2,722,544

U.S.

Martin

11-01-1955

DR

AK

2,797,214

U.S.

Werner Bossard

06-25-1957

DR

BP

4,212.981

U.S.

Yukinaga et al.

07-15-1980

DR

BQ

4,240.820

U.S.

Oickore et al.

12-23-1S80

DR

CV

5,447,957

U.S.

Adams et al.

09-05-1995

DR

DH

5,888,044

U.S.

Widdowson et al.

03-23-1899

DR

Dl

5.691,895

U.S.

Shiraishi et al.

04-06-1999

DR

DL

5,965,573

U.S.

Petris et al.

10-12-1999

DR

DM

6,004,965

U.S.

Breu et al.

12-21-1999

DR

ON

6,005,008

U.S.

Widdowson et al.

12-21-1999

DR

DP

6,020,345

U.S.

Vacher et al.

02-01-2000

DR

DR

6,040,339

U.S.

YoshMa et aL

03-21-2000

DR

DU

6,093,742

U.S.

Salituro et al.

07-25-2000

DR

DV

6,133,319

U.S.

Widdowson

10-17-2000

DR

DY

6,150,415

U.S.

Hammock et al.

11-21-2000

DR

OZ

6,174,901 B1

U.S.

Mantlo et al.

01-16-2001

DR

EA

6,178,399 81

U.S.

Takebayashi et al.

01-23-2001

DR

EB

6,180,675 B1

U.S.

Widdowson et al.

01-30-2001

DR

EC

6,187,799 B1

U.S.

Wood et aL

02-13-2001

DR

ED

6,211,373 B1

U.S.

Widdowson et al.

04-03-2001

DR

EE

6.218,539 B1

U.S.

Widdowson

04-17-2001

DR

EF

6,242,601 B1

U.S.

Breu et al.

08O 5-2001

DR

EG

6,262,113 B1

U.S.

Widdowson et al.

07-17-2001

EH

6,271,261 B1

U.S.

Widdowson

08-07-2001

DR

Ei

6,333,341 B1

U.S.

Mantlo et al.

12-25-2001

DR

EJ

6,339,045 B1

U.S.

Kanno et al.

01-15-2002

DR

EK

6,344,476 81

U.S.

Ranges et al.

02-05-2002

DR

NW

4,546,191

U.S.

Nishlyama et al.

10-08-1985

DR

NX

5,710,094

U.S.

MinamI et al.

01-20-1998

DR

NY

6,380,218

U.S.

Marfat et al.

04-30-2002

Examiner
Signature

/Deepak Rao/

Date

Considered

06/23/2006

+

EXAMINER: Initial if reference considered, whether or not citation Is in conformance with MPEP 609. Draw line through citation if not In conformance
and not considered. Include copy of this form with next communication to applicant

' Unkgue cilatton designation number. ' See attached Kinds of U.S. Patent Documents. * Enter Office that issued the document, by the two-letter code
(WiPO StandanI ST.3). For Japanese patent documents, the indication of the year of the reign of the Emperor must precede the serial number of the
patent document Kind of document by the appropriate symbols as indicated on the document under WIPO Standard ST. 1 6 if possible. * /Applicant is
to place a check mark hee if English language Translation is attached.

Burden Hour Statement This forni is estimated to take 2.0 hours to complete. Time wiO vary depending upon the needs of the individual case. /\ny
comments on the amount of time you are required to complete this form should be sent to the Chief Information Officer. U.S. Patent and Trademark
OfTico, Washington, DC 20231. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: /Assistant Commissioner for
Patents, Washington, DC 20231.

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First Named Inventor

Group Art Unit

\^ Sheet I «- a

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Of

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FOREIGN PATENT DOCUMENTS

Examiner
Initials*

Cite
No.'

Foreign Patent Document

Name of Patentee or Applicant
of Cited Document

Data of Publication
of Cited Document
MM-DD-YYYY

Pages,
Columns,
Unes,
Where
Relevant
Passages or
Relevant
Figures
Appear

T.

Office' Number' "jj^^f

DR

EM

90/02112

WO

The Nutrasweet Co.

03-08-1990

DR

EY

96/10559

WO

Fujis WA Pharmaceutical Co.
Ltd.

04-11-1996

DR

FO

97/17329

WO

Kirin Beer Kabushiki Kaisha

05-15-1997

DR

FF

97/30992

WO

Bristol-Myers Squibb Co.

08-28-1997

DR

FK

98/17267

WO

Zymogenetics, Inc.

04-30-1998

DR

NZ

98/20868

WO

Picower Institute for Med. Res.

05-22-1998

DR

OA

98/45268

WO

Pfizer

10-15-1998

DR

oa

02/14311

WO

Anger

02-21-2002

DR

OC

02/92576

WO

Boehringer Ingelhelm

11-21-02

DR

OO

0S90344 A1

EP

Konica Corp.

01-03-1996

FOREIGN PATENT DOCUMENTS

Examiner
Initisis*

Cite
No.'

Foreign Patent Document

Name of Patentee or Applicant of
Cited Document

Date of
Publication of
Cited Document
MM-DD-YYYY

Pages,
Columns,

Lines,

Where
Relevant
Passages or
Relevant

Figures

T.

Office' Number* Kind Code' (ir
knovm)

DR

FZ

99/32437

WO

Slovako-Farma A.S.

07-01-1999

np

GG

00/43366

WO

KirIn Beer Kabushiki Kaisha

07-27-2000

np

GO

0116932 A1

EP

BASF AG

08-29-1984

DR

HD

0425443 A1

EP

CIBA-GEIGY AG

05-02-1991

DR

HG

0202538 A1

EP

Bayer AG

11-26-1986

DR

HH

0860433 A1

EP

Kirin Beer Kabushiki Kaisha

08-26-1998

DR

HO

25 01 648 A1

DE

The Dow Chemical Co.

07-24-1975

DR

HT

08-301841

JP

Green Cross Corp.

11-19-1996

DR

HV

10-306078

JP

Mitsubishi Chemical Corp.

11-17-1998

Examiner
Signature

/Deepak Rao/

Date

Considered

06/23/2006

EX/VMINER: Initial if reference considered, whether or not citation b In conformance with MPEP 609. Draw Une through citation if not In conformance
and not considered. Include copy of this form with next communk»tion to applicant

Unkjue citaUon designation number. ' See attached Kinds of U.S. Patent Documents. * Enter Office that issued the document, by the two-letter code
(WlPO Standard ST.3). ' For Japanese patent documents, the indication of the year of the reign of the Emperor must precede the serial number of the
patent document Kind of document by the appropriate symbols as Indicated on the document under WlPO Standard ST. 1 6 if possible. " /Applicant Is
to place a check mark hes if English language Translation is attached.

Burden Hour Sutement This form is estimated to take 2.0 hours to complete. Time will vary depending upon the needs of the individual case /\ny
comments on the amount of time you are required to complete this form should be sent to the Chief Informafion Officer, U.S. Patent and Trademark
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OTHER PRIOR ART - NON PATENT LITERATURE DOCUMENTS

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No.

Include name of the author (in CAPITAL LETTERS), title of the article (when appropriate), title of
the item (book, magazine, journal, serial, symposium, catalog, etc.), date, page(s), volume-issue
number<s), publisher, city and/or country wtiere published.

T'

DR

IX

Abstract of EP 0405233A1, Tetouo Sekiya et al.

DR

JR

Grant. A.M. et al.: "Hypotensive thiadiazoles*, J. Mad. Chem. (1972), 15(10), pg. 1082-4.

DR

JS

SL"£xr<t><esis of 2.6-substituted derivatives of 5H-1 ,3,4-thladiazolo>3,2-al-s triazine-5,7-dlone"
FARMACO, ED.SCI. (1978). 3i(12), 972-83

DR

JT

Joseph T. Bruderet al„,Journal of Virology. January 1997, 'Adeiipvinis Infection Stimulates the Raf/MAPK
STgnSling Pathway andlnduces fnteHeuHn-S Expre&slon', May 17, 1998, pgs. 398-404.

DR

JU

Foussard-Blanpin, Odette: 'Comparative pharmacodynamic shidy of variously substituted cartsoxamldes of the
centrafnervous ststem" Ann. PhSirm. Fr. (19S2), 40 (4), pgs. 339-1)50.

DR

MP

Publication No. US 2001A>011136 Al, Publication Date: August 2, 2001, Riedl et al.

DR

MQ

Publication No. US 2001/0016659 A1, Publication Date: August 23, 2001, Riedl et al.

DR

MR

Publication No. US 2001/0027202 Al, Publication Date: October 4, 2001, Riedl et al.

DR

MS

Publication No. US 2002/0165394 A1, Publication Date: November 7, 2002, Dumas et al.

DR

MT

Publication No. US 2002/0042517 A1, Publication Date: >^pril 11, 2002, Uday et al.

DR

MU

Publication No. US 2001/0034447 A1, Publication Date: October 25, 2001, Riedl et aL

DR

MV

Publication No. US 2001/0011135 A1. Publication Date: /Wgust 2, 2001, Riedl etal.

DR

MW

Publication No. US 2002/0103253 Al, Pubfication Date: August 1, 2002, Ranges et al.

Examiner

/Deepak Rao/

Date

Signature

Considered

06/23/2006

+

EX/\MINER: Initial if reference considered, whether or not citation Is In conformance with MPEP 609. Draw line through citation If not in conformance
and not considered. Include copy of this form with next communication to applicant

' Unique citation designation numt)er. ' /applicant is to place a check mark here if English language Translatton Is attached.

Burden Hour Statement This form is estimated to take 2.0 hours to complete. Time will vary depending upon the needs of the indhridual case, fifty
comments on the amount of time you are required to complete this form should be sent to the Chief Information OfTicer. U.S. Patent and Trademark
Office. Washington, DC 20231. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: /VssistanI Commissioner for
Patents, Washington, DC 20231.

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T'

DR

MX

Publication No. US 2001/0008975 A1, Publication Date: July 5. 2001, WoodetaL

DR

MY

Publication No. US 2002/0062763 A1, Publication Date: May 30, 2002, Macholdl et al.

DR

MZ

Publication No. US 2002/0085859 Al, Publication Date: July 4, 2002, Hashimoto et al.

DR

NA

Publication No. US 2002/0085857 Al, Publication Date: July 4, 2002. Kim et al.

DR

NB

Publication No. US 2002/0137774 Al, Publication Date: September 26, 2002, Riedi et al.

DR

NC

Co-pending application Serial No. 09/640,780 tiled August 18, 2000.

DR

ND

Co-pending application Serial No. 09/472,232 tiled December 27, 1999.

DR

NE

Co-pending application Serial No. 09/776,936 filed December 22, 1998.

DR

NF

Co-pending application Serial No. 09/776,935 filed December 22, 1988.

DR

NG

Co-pending application Serial No. 09/993,647 filed November 27, 2001.

DR

NH

Co-pending application Serial No. 10/086,417 filed March 4, 2002.

DR

Nl

Co-pending application Serial No. 10/071.248 filed Febnjary 11, 2002.

DR

NJ

Co-pending application Serial No. 10/303.187 filed December 3, 2002.

DR

NK

Co-pending application Serial No. 10/361,859 filed February 11, 2003.

Examiner
Signature

/Deepak Rao/

Date

Considered

06/23/2006

'EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance
and not considered. Include copy of this form with next communication to applicant

' Unique citation designation numl>er. ' Applicant Is to place a check mark here if English language Translation Is attached.

Burden Hour Statement This form is estimated to take 2.0 hours to complete. Time wiD vary depending upon the needs of the Indhrldual case. Any
comments on the amount of time you are required to complete this form should be sent to the Chief Information OfTicer. U.S. Patent and Trademark
OfTica. Washington. DC 20231. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: /Assistant Commlssk)ner for
Patents. Washington. DC 20231.

Please type a plus sign (+) inside this l>ox | | \^ ^" y PTO/SB/OBA (08-00)

J. _t»'.'^5' Approved for use Uirough 10/31/2002. OMB06S1-0031

^ACti>^.S. Patent and Trademartt Office: U.S. DEPARTMENT OF COMIMERCE
Undef the PapeniCTk Reduction Act of 1995. no persons are required to respond toaoiaecl^

Sulutitute for form 1449/V/PTO

INFORMATION DISCLOSURE
STATEMENT BY APPLICANT

(use as many sheets as necessary)

V Sheet ^ \ of \ S'

Complete If Known

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OTHER PRIOR ART - NON PATENT LITERATURE DOCUMENTS

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Include name of the author (in CAPITAL LETTERS), title of the article (when appropriate), title of
the item (book, magazine, journal, serial, symposium, catalog, etc.), date, page(s), volume-issue
number(s), publisher, city and/or country where published.

T'

DR

NL

Co-pending appiication Serial No. 10/361,644 filed February 11, 2003.

DR

NM

Co-pending application Serial No. 10/361,850 filed February 11. 2003.

DR

NN

Co-pending application Serial No. 10/060,336 filed February 1, 2002.

UK

NO

ww~pcnQing appiicauon oenai no. U9/490,ui4 niBQ uocdTiDcr 1U| loUv.

DR

NP

Co-pending application Serial No. 10/125,369 filed April 19, 2002.

DR

NQ

Co-pending application Serial No. 09/889.227 filed July 1 2, 2001 .

DR

NR

XP-001 145518 # 4956 Potent Raf Kinase Inhibitors from the DIphenylurea Class: Structure /Activity Relationships,
B. Riedl et al., Bayer Corporation.

DR

NS

XP-OO1 145779 "Antitumor Activity of a C-raf Antisense Oligonucleotide in Combination with Standard
Chemotherapeutic Agents against Various Human Tumors Transplanted Subeutansously into Nude Mica*,
Thomas Geiger et al., Vd. 3, 1179-1185, July 1997.

DR

NT

XP-001 14S4B1 +2921 Phase 1 and Pharmacokinetic Study of the Raf Kinase Inhibitor Bay 43-9006 In Patients
with Locally Advanced or Metastic Cancer, Dirk Strumberg et al. Bayer AG.

DR

NU

XP-0022321 30, *A Phase 1 Trial of H-ras Antisense Oligonucleotide ISIS 2503 /Vdministered as a Continuous
Intravenous Infusion in Patients with Advanced Carcinoma", C. Casey Cunningham at al., 2001 American Cancer
Society, Volume 92, Number 5, pages 1265-1271.

DR

NV

XP-0022334S6, MEDLINE/NLM. NLM8336809 - [Intra-arterial ACNU, CODP chemotherapy for brain metastases
from lung cancer: comparison of cases with and without Intra-arterial mannitd infusion], Iwadate Y et al.

DR

OE

Journal of Immunological Methods Berwick 1996, vol. 196 (2) 163-173 corresponding to ON 125-245169

Examiner
Signature

/Deepak Rao/

Date

Considered

06/23/2006

EX/VMINER: Initial if reference considered, whether or not dtation Is In conformance with VPEP 609. Draw line through citation if not In conformance
and not conskf ered. Include copy of this form with next communication to applicant

' Unique citation designation number. ' Applicant Is to place a cheek mark here if English language Translation is attached.

Burden Hour Statement This form Is estimated to take 2.0 hours to complete. Time wiO vary depending upon the needs of the individual case. Any
comments on the amount of time you are required to complete this form should be sent to the Chief Information OfTicer, U.S. Patent and Trademartt
Office, Washington. DC 20231. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: Assistant Commisstoner for
Patents, Washington, DC 20231.

type a plus sign (+) Inside this box

PTO/SB/08A (08-00) ,
Approved for use through 1 0/3t/2002. OMB 0BS1 -0031

ol U S. Patent and Trademark Office: U.S. DEPARTMENT OF COMMERCE

tJnder the Paperwork Reducfion Ad of 1995, fiopereons are reouirBd to respond to a odlecto

itituta for form 1449A/PTO

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09/993,647

November 27, 2001

Bemd RIEDL et al.

1624

Deepak R. RAO

BAYER-18A

U.S. PATENT DOCUMENTS

Examiner
Initials *

Cite No.'

U.S. Patent IJocument

Kind Code'
Number (Uknovm)

Name of Patentee or Applicant
of Cited [}ocumem

Oateof Pulillcation of Cited Document
MM-DD-YYYY

DR

OF

3^84,433

Becker et al.

11-0S-1966

FOREIGN PATENT DOCUMENTS

Examiner
Initials*

Cite No.'

Foreign Patent ISocument

Name of Patentee or Applicant of
Cited Document

DatQcfPulilication of
Cited Document
MM-DD-YYYY

Pages, Columns, Unes,

Where Relevant
Passages or Relevant
Figures Appear

T*

Kind Code'

Offleo' Number* {.ttknomi)

DR

OG

WO

99/28305

A1

Walker

06-10-1999

NON PATENT LITERATURE DOCUMENTS

Examiner
Initials*

Cite No.'

Include name of tlis autlxM- (in CAPITAL LETTERS), title of ttw article (wtien appropriate), tiUe of tlie item (book, magazine,
loumal. serial, symposium, catalog, etc.), date, page(s), volume-issue numbef(s), publisher, dty and/or country wtiere publlstied.

T»

Examiner
Signature

/Deepak Rao/

Date
Considered

06/23/2006

EXAMINER: Initial If reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in
conformance and not considered. Include copy of this form with next communication to applicanL

^ Unique citation designation number. ' See attached Kinds of U.S. Patent Documents. ' Enter Office that issued the document by the two-letter
code (WlPO Standard ST.3). * For Japanese patent documents, Uie Indication of ttio year of the reign of the Emperor must precede the serial
numt>er of the patent documenL Kind of document by the appropriate symbols as indicated on the document under WlPO Standard ST. 16 if
possible. Applicant is to place a check mark here if English language Translation is attached.